The effect of protein-protein and protein-membrane interactions on membrane fouling in ultrafiltration
article
It was studied how protein-protein and protein-membrane interactions influence the filtration performance during the ultrafiltration of protein solutions over polymeric membranes. This was done by measuring flux, streaming potential, and protein transmission during filtration of bovine serum albumin (BSA) solutions at various pH values using various membranes with different cut-off values. It was found that protein-membrane interactions influence the fouling behaviour in the initial stages of filtration. In the high-fouling regime (later stages of filtration), protein-protein interactions dictate the overall performance. AFM images of the membrane surfaces taken after the filtration experiments showed that the membranes were totally covered by a protein fouling layer. The structure of this fouling layer depended strongly on pH. In particular, very open structures with high permeabilities were found at low pH (below the iso-electric point of the protein). These induced high values of flux and protein transmission.
Topics
FoulingPhysicochemical interactionsProtein-membrane interactionsUltrafiltrationAtomic force microscopyMechanical permeabilityPH effectsUltrafiltrationBovine serum albuminPolymeric membranesElectrolytePolysulfoneMembrane technologyArtificial membraneAtomic force microscopyMembrane permeabilityMembrane transportProtein analysisProtein protein interactionProtein transport
TNO Identifier
56898
ISSN
03767388
Source
Journal of Membrane Science, 179(1-2), pp. 79-90.
Place of publication
Amsterdam
Pages
79-90
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