Predictive testing for pathogenic autoimmunity : the morphological approach
article
The term autoimmunity refers to physiologically normal immune processes against self-antigens. In rare cases, the regulatory mechanisms become deflective and the uncontrolled production of autoantibodies or activation of autoreactive T-cells can subsequently cause disease. Substances may be capable of evoking autoimmune disease, and it is a challenge in routine toxicology to recognize such substances. In in vivo toxicity studies, uncommon inflammation in exposed animals should be discussed in terms of non-immune toxicity (e.g. irritation), infection, allergy and autoimmunity, taking into account that a response in even a few animals may be significant. Moreover, early morphological indicators of inflammation and lymphoid organ alterations can direct further investigation. Copyright (C) 2000 Elsevier Science Ireland Ltd.
Topics
GranulomaInduction of autoimmune diseaseLymphoid organsMononuclear cell infiltratesAutoimmune diseaseCell infiltrationConference paperHistologyHumanImmunohistochemistryInflammationLymphoid organPriority journalPrognosisRisk assessmentAnimalsAutoimmune DiseasesAutoimmunityHumansInflammationLymphoid TissuePredictive Value of TestsAnimalia
TNO Identifier
56708
ISSN
03784274
Source
Toxicology Letters, 112, pp. 433-442.
Pages
433-442
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