Computer-aided biokinetic modelling combined with in vitro data
article
Within the framework of in vitro alternatives for in vivo safety assessment, the kinetic behaviour of a compound can be described by biokinetic models. These models, with emphasis on the physiologically based pharmacokinetic models, need a variety of biological, physicochemical and biochemical parameters. This paper deals with the possibilities for obtaining these data from in vitro studies. Examples are given for parameters on absorption (both dermal and intestinal), distribution and metabolism.
TNO Identifier
37105
ISSN
08872333
Source
Toxicology in Vitro, 9(4), pp. 537-542.
Pages
537-542
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