Heat sensitivity of rat skin
article
Experiments were conducted to determine the heat sensitivity of normal tissues. The rat skin was selected as a suitable model. After inflation of the rat subcutis with air, anaesthetized animals were placed in a heated water bath with the upper part of this air pouch exposed to the hot water. A total of 502 animals were treated with temperatures ranging from 42 to 47°C and exposure times of from 12 to 240 min. The intensity of damage was divided into 6 grades ranging from "no effect" to "maximum effect". The relationship between the exposure time to heat and the required temperature for isoeffect damage was determined and expressed as t = a × b^τ, with a value of 0.51 for b(t = exposure time; T = temperatures; a = constant). The synergistic effect of heat combined with X-irradiation was also studied. When animals were X-irradiated within 6 hr after heat treatment, the synergistic effect was evident, but disappeared after 24 hr.
Chemicals/CAS: Water, 7732-18-5
Chemicals/CAS: Water, 7732-18-5
Topics
TNO Identifier
228470
ISSN
02775379
Source
European Journal of Cancer and Clinical Oncology, 14(11), pp. 1161-1166.
Pages
1161-1166
Files
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