Modelling of in vivo distribution dynamics of daunomucin, an anticancer drug
conference paper
The dynamic system of in vivo drug distribution and elimination is often described with a two- or three-compartment model. The wide range of severe toxicities inherent to anticancer drugs however, makes it necessary to predict concentration levels in many specific tissues as function of time after administration. We have tested a series of multi-compartment models (up to 22 compartments, with various pathway options for drug transport), with first order differential equations to describe distribution and metabolism kinetics after a pulse shaped input. Parameter optimization in the Maximum Likelihood sense yielded satisfactory results for parent drug; predicted metabolite concentrations showed poorer fits to observed data, perhaps due to non-linearities.
Topics
TNO Identifier
229929
ISSN
07411146
Source title
Identification and System Parameter Estimation 1985, Proceedings of the Seventh IFAC/IFORS Symposium., York, Engl, Conference code: Conference code: 10070
Place of publication
Oxford
Pages
1391-1396
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