Sublethal damage repair and radiosensitivety of human squamous cell carcinoma cells grown with different cuture techniques
article
In this study, cells of a human squamous cell carcinoma line, HN-1, were grown in monolayers and as multicellular tumour spheroids (MTS). Repair of radiation-induced damage was studied by irradiation with single and split doses of X rays (4-8 Gy). It was shown that the amount of sublethal damage that was repaired in this dose range was equal in cells growing in monolayers and as MTS. The radiosensitivity of spheroids, as expressed by spheroid "cure" dose, increased with increasing MTS diameter. It is postulated that, in MTS with no signs of hypoxia, radioresistance diminishes when MTS increase in diameter.
TNO Identifier
268946
Source
British Journal of Radiology, 62(744), pp. 1084-1088.
Pages
1084-1088
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