Effectiveness of continuous low dose rate gamma irradiation on rat skin
article
A skin transplantation technique has been employed for assessment of radiation induced damage to rat skin. Shrinkage of the area of an irradiated piece of white skin was measured five months after transplantation into brown F1 hybrid rats. The effectiveness of 137Cs γ rays at a dose rate of 85 rads/hr was compared with that of 300 kV X rays applied at 40 rads/min. Protracted irradiation provides a large sparing effect due to repair of sublethal damage. For a 90% reduction of skin area, the ratio of the doses given at low and high dose rate, respectively, is 1.8. Comparison of these results with data obtained previously for a rat rhabdomyosarcoma, indicates that protracted irradiation at low dose rate, when compared with acute irradiations, has a larger sparing effect on skin than on the tumour.
Chemicals/CAS: cesium 137, 10045-97-3
Chemicals/CAS: cesium 137, 10045-97-3
Topics
cesium 137radioisotopegamma radiationhistologymethodologyratskinskin grafttheoretical studyX rayAnimalCell SurvivalClone CellsDose-Response Relationship, RadiationFemaleNeoplasms, ExperimentalRadiation DosageRadiation EffectsRadiation Injuries, ExperimentalRadiodermatitisRatsRhabdomyosarcomaSkinSkin TransplantationTime FactorsTransplantation, Homologous
TNO Identifier
227694
ISSN
00071285
Source
British Journal of Radiology, 47(562), pp. 673-678.
Pages
673-678
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