The anti-arthritic and immunosuppressive effects of cyclosporin A on collagen-induced arthritis in the rhesus monkey
article
The influence of cyclosporin A (CsA) on type II collagen-induced arthritis (CIA) in the rhesus monkey has been investigated. CsA was administered subcutaneously in a dose of 25 mg/kg per day during 9-18 days and additionally 12.5 mg/kg per day for 7 days. At this dosing regime no significant alterations of haematologic parameters were found, indicating that the toxicity of CsA was negligible. Administration of CsA after onset of arthritis had no beneficial effect, but when given between immunization and manifestation of clinical symptoms, CIA could be prevented completely. Moreover, these monkeys became resistant to the disease, because no arthritic activity could be observed upon a booster immunization with type II collagen (CII). The suppression of disease by CsA is reflected in reduced antibody levels to CII. Chemicals/CAS: acetylsalicylic acid, 493-53-8, 50-78-2, 53663-74-4, 53664-49-6, 63781-77-1; buprenorphine, 52485-79-7, 53152-21-9; cortisone, 53-06-5; cyclosporin A, 59865-13-3, 63798-73-2; dexamethasone, 50-02-2; phenylbutazone, 129-18-0, 50-33-9, 8054-70-4; prednisolone, 50-24-8; Collagen, 9007-34-5; Cyclosporine, 59865-13-3
Topics
collagen arthritiscyclosporin Arhesus monkeyacetylsalicylic acidaspesicbuprenorphinecollagen type 2cortisonecyclosporin adexamethasonedexatomanolphenylbutazoneprednisoloneprisantolunclassified druganimal experimentanimal modelanimal tissuearthritisarticlecontrolled studyimmunizationintramuscular drug administrationmalenonhumanpriority journalrhesus monkeysubcutaneous drug administrationAnimalAntibody FormationArthritis, RheumatoidBlood Cell CountBlood Chemical AnalysisCollagenCyclosporineDisease Models, AnimalMacaca mulattaMale
TNO Identifier
232208
ISSN
00099104
Source
Clinical and Experimental Immunology, 93(3), pp. 318-322.
Pages
318-322
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