The haematopoietic stem cell in Rauscher virus induced erythroblastosis of BALB/c mice

article

Brommer, E.J.P.

Bentvelzen, P.
The relative number of hematopoietic stem cells in the spleen of Rauscher erythroblastosis virus infected BALB/c mice remains approximately constant throughout the course of the disease. These stem cells have a normal differentiative capacity, as judged from the distribution of histological types of spleen colonies in irradiated recipients. Incubation of spleen cell suspensions with rabbit antisera to the virus leads to a drastic reduction in stem cells, indicating the presence of the virus in these cells. A lesser sensitivity to normal rabbit serum indicates the partial loss of xenogeneic antigen on the surface of infected stem cells.
Chemicals/CAS: Immune Sera
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membrane antigenvirus antibodybone marrow cellcell membranecell suspensionerythroblastosishematopoiesishematopoietic cellleukemialeukemia cellmousemurine leukemia virusoncovirinaerauscher leukemia virusspleenspleen celltheoretical studyvirus infectionAnimalCell CountCell DivisionClone CellsFemaleFluorescent Antibody TechniqueHematopoietic Stem CellsImmune SeraImmunodiffusionLeukemia, ExperimentalLeukemia, LymphocyticLeukocyte CountMiceMice, Inbred BALB CRabbitsRauscher VirusSpleen
TNO Identifier
227704
Repository link
https://resolver.tno.nl/uuid:60663de5-31bc-4164-bb27-fd4edd1227a5
DOI
https://dx.doi.org/10.1016/0014-2964(74)90141-8
ISSN
02775379
Source
European Journal of Cancer and Clinical Oncology, 10(12), pp. 827-833.
Pages
827-833
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