Are cell kinetic data relevant for the design of tumour chemotherapy schedules?
article
The data on the importance of the application of information on cell kinetics for the success of tumor chemotherapy are critically reviewed. It is concluded that the data on cell sensitivity to drugs as affected by cell kinetic variables are as yet insufficient to permit the prediction of optimal dosage schedules for tumor therapy. More information is needed on differential responses and differential kinetic features of normal and malignant tissues. Optimistic views of cell kinetics as an easy answer to the problems of drugs dosage schedule design are unjustified, but so is the disenchantment with cell kinetics as a fruitful approach. Much further work, especially on the drug sensitivity of cellular compartment in slow growing tumors, is needed before a complete evaluation of this tool is possible. (54 references).
Chemicals/CAS: azathioprine, 446-86-6; busulfan, 55-98-1; carmustine, 154-93-8; chlorambucil, 305-03-3; chlormequat, 7003-89-6, 999-81-5; chlormethine, 51-75-2, 55-86-7, 82905-71-3; cyclophosphamide, 50-18-0; cytarabine, 147-94-4, 69-74-9; dichlorodiethylamine, 334-22-5, 821-48-7; dimethylbusulfan, 55-93-6; emetine, 316-42-7, 483-18-1; fluorouracil, 51-21-8; ifosfamide, 3778-73-2; melphalan, 148-82-3; mercaptopurine, 31441-78-8, 50-44-2, 6112-76-1; methotrexate, 15475-56-6, 59-05-2, 7413-34-5; optalidon, 60382-50-5; procarbazine, 366-70-1, 671-16-9; teniposide, 29767-20-2; vinblastine, 865-21-4; vincristine, 57-22-7; Antineoplastic Agents
Chemicals/CAS: azathioprine, 446-86-6; busulfan, 55-98-1; carmustine, 154-93-8; chlorambucil, 305-03-3; chlormequat, 7003-89-6, 999-81-5; chlormethine, 51-75-2, 55-86-7, 82905-71-3; cyclophosphamide, 50-18-0; cytarabine, 147-94-4, 69-74-9; dichlorodiethylamine, 334-22-5, 821-48-7; dimethylbusulfan, 55-93-6; emetine, 316-42-7, 483-18-1; fluorouracil, 51-21-8; ifosfamide, 3778-73-2; melphalan, 148-82-3; mercaptopurine, 31441-78-8, 50-44-2, 6112-76-1; methotrexate, 15475-56-6, 59-05-2, 7413-34-5; optalidon, 60382-50-5; procarbazine, 366-70-1, 671-16-9; teniposide, 29767-20-2; vinblastine, 865-21-4; vincristine, 57-22-7; Antineoplastic Agents
Topics
azathioprinebusulfancarmustinechlorambucilchlormequatchlormethinecyclophosphamidecytarabinedichlorodiethylaminedimethylbusulfanemetinefluorouracilifosfamideimidazole derivativemelphalanmercaptopurinemethotrexateoptalidonprocarbazineteniposidetriazine derivativevinblastinevincristine4' norepipodophyllotoxin derivativebone marrow cellcancercancer chemotherapycancer growthcell kineticscell proliferationchemotherapycytokinesisdose responsedrug sensitivityfumaric acid 3 formylphenyl esterhematopoiesismousereviewAntineoplastic AgentsCell DivisionCell SurvivalHematopoietic Stem CellsHumanKineticsLeukemiaModels, BiologicalNeoplasms
TNO Identifier
227687
ISSN
00088730
Source
Cell and Tissue Kinetics, 7(5), pp. 493-504.
Pages
493-504
Files
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