Interactions between differentiation and leukaemogenesis in Rauscher murine leukaemia

bookPart

Brommer, E.J.P.

Bentvelzen, P.
In erythroblastosis induced by Rauscher murine leukemia virus, normally functioning hemopoietic stem cells were present, capable of restoring lethally irradiated mice. In the spleen the number of pluripotent stem cells increased considerably. Absorbed rabbit antiserum to the virus was cytotoxic to the stem cells in leukemic spleens, indicating the presence of viral antigens on the surface of these cells. Sensitivity of the leukemic stem cell to normal rabbit serum decreased strongly. Not only erythropoietic but also antigenic and thrombopoietic stimuli promoted the splenomegaly induced by the virus. The radio sensitivity of the leukemic response resembled that of the pluripotent stem cell. It is postulated that the virus infects the hemopoietic system at the level of the stem cell; transformation requires a differentiating stimulus.
Chemicals/CAS: Antigens, Viral; Immune Sera
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virus antigenantiserumetiologyhematopoiesisleukemogenesismousesplenomegalythrombocytopoiesisvirus leukemiacancer transplantationHematopoietic stem cellImmunologyMouse strainRauscher leukemia virusThrombocytesAntigens, ViralBlood PlateletsCell DifferentiationCytotoxicity Tests, ImmunologicErythrocytesFemaleHematopoietic Stem CellsImmune SeraLeukemia, ExperimentalMiceMice, Inbred BALB CNeoplasm TransplantationRabbitsRadiation ChimeraRauscher VirusSpleenSplenomegaly
TNO Identifier
227484
Repository link
https://resolver.tno.nl/uuid:e7903ab2-a708-4099-b4d0-e37ee12043ba
Publisher
Karger
Source title
Unifying Concepts of Leukemia, Bibliotheca Haematologica
Editor(s)
Duthcer, R.M.
Chieco-Bianch, L.
Place of publication
Basel
Pages
929-934
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