Albumin synthesis by liver parenchymal cells isolated from young, adult and old rats

article


Bezooijen, C.F.A. van

Grell, T.

Knook, D.L.
Isolated liver parenchymal cells were incubated in a modified Waymouth medium under an oxygen tension of 30x103 Pa at pH 7.8. Under these conditions, hepatocytes from 3 mth old rats synthesized 5.8 μg albumin/h/106 cells. This value nearly equals the synthesizing capacity of intact liver tissue and is the highest activity reported so far for isolated liver cells. Parenchymal cells isolated from 36 mth old rats synthesized more albumin as compared to cells from 3 mth old rats. The albumin synthesizing capacity of cells isolated from 12 mth old rats was less than that of cells from 3 mth old rats.
Chemicals/CAS: Serum Albumin
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albuminageagingcell culturein vitro studyliver cellliver functionmethodologyprotein synthesisrattheoretical studyAgingAnimalFemaleImmunodiffusionKineticsLiverRatsRats, Inbred StrainsSerum Albumin
TNO Identifier
228036
Repository link
https://resolver.tno.nl/uuid:db75d53a-7aab-483d-9954-c223a9e73107
ISSN
0006291X
Source
Biochemical and Biophysical Research Communications, 71(2), pp. 513-519.
Pages
513-519
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