Current experience using the laboratory rat in aging studies
article
The breeding and maintenance conditions for 2 strains of inbred rats, the WAG/Rij and BN/Bi rats, are described. The survival characteristics of these 2 strains are compared with those of 2 other experiments in which rats were kept for longevity studies under different environmental conditions of microbiologic status and diet. Data are provided on the rate and types of spontaneous tumors in the 2 strains. It can be concluded that in order to obtain rats of good quality and in sufficient numbers for aging studies, breeding and raising the animals under strict SPF conditions is necessary, just as it is to maintain them under 'clean conventional' conditions for long term studies.
Topics
TNO Identifier
228003
Source
Laboratory Animal Science, 26(2 II), pp. 320-328.
Pages
320-328
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