Synthesis, characterization and in vitro antitumour activity of a series of substituted 2,2-di-n-butyl-4-oxo-benzo-1,3,2-dioxastannins
article
The characterization by 1D and/or 2D 1H NMR, 13C NMR, 119Sn NMR, Mössbauer and mass spectrometry of a series of di-n-butyltin derivatives of 3-, 4-, and 5-methyl-, 3-, 4-, and 5-methoxy-, 4- and 5-amino-substituted, and 3,5-diiodo-salicyclic acids is described. Their NMR spectra suggest that they are present as dimers in CDCl3 solution, like the di-n-butyltin derivative of unsubstituted salicyclic acid. This has been confirmed by the observation of mixed dimers. The insoluble derivatives have been characterizerd by solid state cross polarization/magic angle spinning (CP/MAS) 13C and/or 119Sn NMR, Mössbauer and mass spectroscopy. These compounds are characterized in vitro by a lower inhibition dose than cis-platin or etoposide against a series of five human cell lines. Copyright © 1990 John Wiley & Sons Ltd.
TNO Identifier
573222
ISSN
02682605
Source
Applied Organometallic Chemistry, 4(4), pp. 335-343.
Pages
335-343
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