Rbe-LET relations for induction of reproductive death and chromosome aberrations in mammalian cells

conference paper
Barendsen, G.W.
Published data on the effectiveness of different radiations for induction of cell reproductive death and chromosome aberrations, measured for a variety of mammalian cells, have been analysed with respect to components of damage increasing as a linear and a quadratic function of the dose, respectively. This analysis has shown that a large variation in the several characteristic parameters is obtained for the various types of cells studied. Furthermore, significant differences are deduced between values of some of the corresponding parameters for cell inactivation and chromosome aberrations, respectively. These differences are shown to be important with respect to the interpretation of yield versus dose curves for tumour induction.
Topics




















Animal cellsBiological radiation effectsCarcinogenesisCell killingChromosomal aberrationsDose-response relationshipsGamma radiationLETMicrodosimetryRBESurvival curvesX radiationBiological effectsDosimetryElectromagnetic radiationEnergy transferIonizing radiationsMutationsPathogenesisRadiation effectsRadiations
TNO Identifier
353174
Repository link
https://resolver.tno.nl/uuid:2127c6f8-a212-4e13-8b16-a05d85583f53
ISBN
0-906346-02-9
Publisher
International Atomic Energy Agency (IAEA)
Source title
6th Symposium on microdosimetry, 22-26 May 1978, Brussels, Belgium
Editor(s)
Booz, J.
Ebert, H.G.
Place of publication
Vienna
Pages
55-68
Files
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