Pretransplant blood transfusions have an additive positive effect on kidney graft prognosis in D/DR-matched rhesus monkeys
article
The effect of blood transfusions on kidney graft survival in D/DR-matched host-donor combinations was investigated in rhesus monkeys treated with azathioprine and prednisolone. If host-donor combinations were mismatched for D/DR and no transfusions were given (controls), graft survival ranged from 9 to 22 days. D/DR matching alone led to survival times of 13 to 66 days with 62% of the animals showing a prolonged survival time (>22 days). However, when three pretransplant blood transfusions were given in D/DR-matched combinations, the range of graft survival was even better: 19 to 73 days with 90% of the recipients surviving for longer than 22 days. The recipients in this group also had a better kidney function in the first weeks after transplantation than that of the nontransfused D/DR-matched group. Therefore, the beneficial effects of D/DR matching and pretransplant transfusions are additive in the rhesus monkey. Chemicals/CAS: azathioprine, 446-86-6; prednisolone, 50-24-8; Creatinine, 60-27-5; Histocompatibility Antigens Class II
Topics
azathioprineprednisoloneanimal experimentblood and hemopoietic systemimmunosuppressive treatmentintramuscular drug administrationmonkeyBlood TransfusionCreatinineFemaleGraft SurvivalHistocompatibility Antigens Class IIHistocompatibility TestingKidney TransplantationMacacaMacaca mulattaMalePreoperative CarePrognosisSupport, Non-U.S. Gov'tTime Factors
TNO Identifier
229053
ISSN
00411337
Source
Transplantation, 32(1), pp. 48-50.
Pages
48-50
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