Attempts to induce immunological enhancement for kidney allografts in rhesus monkeys. I. Effect of various alloantisera, including B cell antisera
article
Various rhesus alloantisera were tested for their capacity to induce enhancement of kidney allograft survival in D locus-incompatible rhesus monkeys. Six experimental groups were investigated: 1, ten allografted monkeys remained untreated; 2, six recipients were treated with Imuran and prednisolone; 3, eight rhesus monkeys were treated with a polyspecific 'anti-SD' serum; 4, four animals were given oligospecific antikidney serum; 5, four monkeys were treated with oligospecific antiblood serum; and 6, nine recipients were given anti-Ia-like sera plus immunosuppressive treatment with Imuran and prednisolone. It was found that neither treatment with Imuran and prednisolone nor the administration of any of the alloantisera had a substantial effect on kidney graft survival. However, there appeared to be a difference in renal function among experimental groups. At 6 days after grafting, the mean blood urea level in the group treated with Ia-like antisera was found to be significantly lower than those of all other groups. It is discussed that this favorable effect is attributable to treatment with anti-Ia-like sera and not to the additional factors (conventional immunosuppression and partial matching for Ia-like antigens) occurring in this experimental group.
Chemicals/CAS: Antigen-Antibody Complex; Azathioprine, 446-86-6; Histocompatibility Antigens; Immune Sera; Isoantibodies; Isoantigens; Prednisolone, 50-24-8
Chemicals/CAS: Antigen-Antibody Complex; Azathioprine, 446-86-6; Histocompatibility Antigens; Immune Sera; Isoantibodies; Isoantigens; Prednisolone, 50-24-8
Topics
alloantibodylymphocyte antibodyallograftanimal experimentimmunostimulationkidneykidney transplantationmonkeytheoretical studyAnimalAntigen-Antibody ComplexAzathioprineB-LymphocytesGraft SurvivalHaplorhiniHistocompatibility AntigensImmune SeraImmunosuppressionIsoantibodiesIsoantigensKidneyKidney TransplantationMacacaMacaca mulattaPrednisoloneTransplantation, Homologous
TNO Identifier
228485
ISSN
00411337
Source
Transplantation, 25(4), pp. 188-192.
Pages
188-192
Files
To receive the publication files, please send an e-mail request to TNO Repository.