Ia-Like antigens of rhesus monkeys: current state of serology and genetics
article
Current knowledge of a new type of serologically defined (SD) membrane antigen of primates, the Ia like determinants, is summarized, and some provisional conclusions are drawn. Cytotoxic antibodies primarily reactive with B lymphocytes can be routinely produced in rhesus monkeys; some of these antibodies identify specificities with characteristics resembling those of the murine Ia antigens since they are controlled by the MHC, have a similarly restricted tissue distribution and are biochemically distinct from conventional SD antigens; and provisional mapping of the genes controlling the Ia like specificities suggests that at least 3 are situated in a segment of RhL A to the right of LD1 (LD1 lymphocyte defined) and Ir GL (Ir genes controlling humoral responses to glutamic acid and lysine). Furthermore, a provisional population and family analysis permitted the postulation of two segregant series of 4 genes each and one of these series was best placed to the right of the SD1 locus of RhL A (compare with HLA). If these conclusions are correct, then the antibodies defining Ia like specificities are not likely to identify the stimulator antigens of the LD1 locus: first, one of the postulated allelic series is controlled by a different region of RhL A; secondly, excellent B cell alloantibodies were raised by immunization with donors which did not stimulate the serum producer in MLC; and thirdly, the distribution of Ia like antigens in unrelated monkeys has so far not shown positive associations with patterns obtained with so called LD typing cells. Consequently, if the region where LD1 and Ir genes are situated is regarded as the monkey's I or immune response region, it follows that the B cell alloantigens described in this report should not be called 'Ia like', at least if we assume that all components of the murine I region (LD, Ir and Ia) were displaced 'en bloc' to the left or right of the SD region in the primates' MHC. However, if multiple translocations have taken place, the mapping of the LD1 locus and certain Ir genes in regions different from those coding for the described B cell alloantigens is not surprising. Consequently, the identified Ia like specificities might well be the monkey's analogues of the murine Ia antigens. Whatever the truth, it is of major interest that so many important marker loci of the MHC have managed to retain close linkage in the course of evolution. The minor 'rearrangements' of loci within the complex as reported here seem to be of secondary importance.
Chemicals/CAS: Epitopes; Histocompatibility Antigens; Immunoglobulins, Surface
Chemicals/CAS: Epitopes; Histocompatibility Antigens; Immunoglobulins, Surface
Topics
alloantibodyIa antigenepitopehistocompatibility antigenlymphocyte membrane immunoglobulinb lymphocytecapping phenomenonimmune responsein vitro studylymphocyte defined antigenmajor histocompatibility complexmixed lymphocyte reactionmonkeyserologically defined antigentheoretical studyanimalantibody productionantibody specificitychromosome mapHaplorhiniimmunogeneticsimmunologyMacacaphenotypepopulation geneticsreviewAnimalAntibody FormationAntibody SpecificityChromosome MappingEpitopesGenetics, PopulationHaplorhiniHistocompatibility AntigensImmunogeneticsImmunoglobulins, SurfaceMacacaMacaca mulattaPhenotype
TNO Identifier
228045
Source
Transplantation Reviews, 30, pp. 3-17.
Pages
3-17
Files
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