Evidence for two linked loci controlling the serologically defined leukocyte antigens of chimpanzees (ChL A)
article
Eleven serologically defined (SD) leukocyte specificities of chimpanzees are described. The results of a limited population analysis of unrelated animals and of family studies were compatible with genetic control of those specificities by alleles of 2 different loci. Close linkage between these loci, although not formally proved, is likely on the basis of the segregation patterns of the specificities in the families. Serological similarities between specificities of the first and second series of chimpanzees and those of the LA and FOUR series of the human HL A complex (respectively) support the assumption that gene products of 2 linked SD loci are identified as belonging to the chimpanzee's major histocompatibility complex, ChL-A.
Chemicals/CAS: Antilymphocyte Serum; Epitopes; Histocompatibility Antigens; Immune Sera; Isoantibodies
Chemicals/CAS: Antilymphocyte Serum; Epitopes; Histocompatibility Antigens; Immune Sera; Isoantibodies
Topics
antigenlymphocyte antigentransplantation antigenhistocompatibilityhistocompatibility complexHLA systemimmunogeneticsmodelmonkeyserologytheoretical studyAllelesAnimalAntilymphocyte SerumChromosome MappingEpitopesFemaleGenotypeHeterozygoteHistocompatibility AntigensImmune SeraIsoantibodiesLymphocytesMalePan troglodytesPedigreePhenotype
TNO Identifier
227705
ISSN
0001-2815
Source
Tissue Antigens, 4(4), pp. 313-328.
Pages
313-328
Files
To receive the publication files, please send an e-mail request to TNO Repository.