The histocompatibility complex of rhesus monkeys: I. Serology and genetics of the RhL A system
article
Rhesus monkeys have a major system of serologically defined histocompatibility antigens, called RhL A. Like the analogous human system (HL A), RhL A is highly polymorphic, and its antigens are controlled by 2 closely linked segregant series of alleles. About 50% of the gene products of both allelic series can now be identified serologically. Recombination frequency within the RhL A region is approximately 1%. The relevance of RhL A to histocompatibility was proved by intersib skin grafting experiments. The influence of matching for RhL A on graft survival in unrelated host/donor combinations is equivocal. A genetic locus exerting a major influence on mixed lymphocyte reactivity has been identified and found to be closely linked to the RhL A region.
Chemicals/CAS: Histocompatibility Antigens; Immune Sera; Rh-Hr Blood-Group System
Chemicals/CAS: Histocompatibility Antigens; Immune Sera; Rh-Hr Blood-Group System
Topics
transplantation antigenhistocompatibilityHLA systemlymphocyte culturemonkeyskin graftskin graft rejectiontheoretical studyAnimalAntibody FormationAntibody SpecificityBlood PlateletsComplement Fixation TestsCross ReactionsCytotoxicity Tests, ImmunologicFemaleGenotypeGraft RejectionHaplorhiniHistocompatibilityHistocompatibility AntigensHistocompatibility TestingImmune SeraImmunizationLeukocytesLymphocytesMacacaMaleMethodsPhenotypeRh-Hr Blood-Group SystemTissue SurvivalTransplantation, Homologous
TNO Identifier
227515
ISSN
0001-2815
Source
Tissue Antigens, 3(4), pp. 257-272.
Pages
257-272
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