The facilitation of tumour growth in the lung by cyclophosphamide in artificial and spontaneous metastases models
article
It had been shown previously that treatment of mice with cyclophosphamide before i.v. inoculation of tumour cells enhanced the growth of lung colonies. Results presented here show that treatment with cyclophosphamide after i.v. inoculation of tumor cells could also decrease host resistance against growth of lung colonies. This enhancement could be counteracted by pretreatment with cortisone acetate and is hardly influenced by increasing the tumour load or by dose fractionation of cyclophosphamide. In addition, the increased lung colony formation in the artificial model, with i.v. inoculation of tumour cells, was also present in a tumour model in which spontaneous metastases occur. However, the growth promoting effect of cyclophosphamide is for most tumours quantitatively negligible in comparison to the antitumour effect of the drug.
Chemicals/CAS: cortisone acetate, 50-04-4; cyclophosphamide, 50-18-0; fluorouracil, 51-21-8; ifosfamide, 3778-73-2; methotrexate, 15475-56-6, 59-05-2, 7413-34-5; Cyclophosphamide, 50-18-0
Chemicals/CAS: cortisone acetate, 50-04-4; cyclophosphamide, 50-18-0; fluorouracil, 51-21-8; ifosfamide, 3778-73-2; methotrexate, 15475-56-6, 59-05-2, 7413-34-5; Cyclophosphamide, 50-18-0
Topics
cortisone acetatecyclophosphamidefluorouracilifosfamidemethotrexateanimal experimentbonecancer growthcorynebacterium parvumdrug comparisondrug responsehost resistanceimmunologylewis carcinomalung tumormetastasismodelmouseosteosarcomarespiratory systemsection 37subcutaneous drug administrationAnimalCell SurvivalComparative StudyCyclophosphamideDisease Models, AnimalGraft SurvivalImmunotherapyLung NeoplasmsMiceMice, Inbred StrainsNeoplasms, ExperimentalPropionibacterium acnesSupport, U.S. Gov't, P.H.S.Time Factors
TNO Identifier
228747
ISSN
02775379
Source
European Journal of Cancer and Clinical Oncology, 15(9), pp. 1139-1149.
Pages
1139-1149
Files
To receive the publication files, please send an e-mail request to TNO Repository.