Adjuvant chemotherapy : Theoretical considerations and model studies
bookPart
Comparison of response of experimental tumors to adjuvant chemotherapy for minimal disease with the response of solid large tumors to similar drug regimens has indicated that for many tumors the small microscopic foci are more responsive. There are, however, a number of model tumors that respond far less to chemotherapy when applied to minimal disease than when applied to large tumors. The response of these tumors to adjuvant treatment shows similarities with the clinically observed response. The data do not support the hypothesis that the success of a drug combination given as adjuvant chemotherapy may be predicted from the success of the same treatment when applied for manifest disease.
Chemicals/CAS: cyclophosphamide, 50-18-0; fluorouracil, 51-21-8; methotrexate, 15475-56-6, 59-05-2, 7413-34-5; Antineoplastic Agents
Chemicals/CAS: cyclophosphamide, 50-18-0; fluorouracil, 51-21-8; methotrexate, 15475-56-6, 59-05-2, 7413-34-5; Antineoplastic Agents
Topics
adjuvantcyclophosphamidefluorouracilmethotrexateantineoplastic agentanimal experimentbiological modelcancer chemotherapycytotoxicitymousetheoretical studytherapytumoranimalcell countcell divisioncell survivalcomparative studydisease modeldrug combinationdrug effectdrug resistanceexperimental neoplasmmetastasispathologyAnimalAntineoplastic AgentsCell CountCell DivisionCell SurvivalComparative StudyDisease Models, AnimalDrug ResistanceDrug Therapy, CombinationMiceNeoplasm MetastasisNeoplasms, Experimental
TNO Identifier
228689
Publisher
Springer
Source title
Adjuvant Therapies and Markers of Post-Surgical Minimal Residual Disease - I: Markers and General Problems of Cancer Adjuvant Therapies
Editor(s)
Bonadonna, G.
Mathé, G.
Salmon, S.E.
Mathé, G.
Salmon, S.E.
Place of publication
Berlin
Pages
119-125
Files
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