Synthesis, Spectroscopic Characterization and Antitumour Activity of Diorganotin(IV) Derivatives of N-Substituted Ortho-Aminobenzoic Acid
article
Four compounds of the type [(o-RNH-C6H4COO)(CH3CH2CH2CH2)2Sn]2O and [(o-CH3NH-C6H4COO)(CH3)2Sn]2O have been prepared, characterized by 1H, 13C, 119Sn NMR, and by Mössbauer and mass spectrometry. They have been tested in vitro against two human tumour cell lines, nl. MCF-7 (mammary tumour) and WiDr (colon carcinoma), and found to score slightly better than cis-platin but markedly less than other cytostatic agents. Copyright © 1991 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
TNO Identifier
572705
ISSN
00379646
Source
Bulletin des Sociétés Chimiques Belges, 100(5), pp. 367-374.
Pages
367-374
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