Concentration and distribution of nucleic acids in normal and atherosclerotic human aortas
article
Quantitative determinations of the nucleic acids in normal and atherosclerotic human aortic tissues were carried out. Intima (lesions removed), media (lesions removed), fatty streaks and spots, plaques and atheromas of the thoracic aorta at the various stages of atherosclerosis were separately analysed. A marked decrease was found in the deoxynucleic acid (DNA) level in the intima and the media from stage 0 to stage I. The DNA level in the more advanced lesions was significantly lower than that in the surrounding apparently unaffected tissue. From the observed RNA/DNA ratios it is concluded that the RNA content of the tissue-cells gradually increases in the course of the disease. Copyright © 1972 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
TNO Identifier
572313
ISSN
01650513
Source
Recueil des Travaux Chimiques des Pays-Bas, 91(11), pp. 1319-1328.
Pages
1319-1328
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