Proliferation behaviour of P and Q cells in a rat rhabdomyosarcoma after irradiation as determined by DNA measurements

article
Kal, H.B.
DNA distributions of R 1 tumour cells from a transplantable rat rhabdomyosarcoma grown in vitro and in vivo have been obtained at different time intervals after irradiation with 2000 rad of 137Cs gamma rays. From the changes observed in the DNA histograms, the following conclusions can be drawn: Changes in the fractions of cells in G1, S and G2+M phases are similar for R 1 cells cultured in vitro and R 1 cells irradiated in the tumour. Non proliferating cells (Q cells) have a DNA content equal to that of G1 and S phase cells. Up to 20 hr after irradiation no recruitment of Q cells could be observed. R 1 tumour cells can quite easily be distinguished from normal cells present in the tumour due to differences in DNA content.
Chemicals/CAS: cesium 137, 10045-97-3; DNA, 9007-49-2; Cesium Isotopes; DNA, 9007-49-2
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cesium 137dnacancer cellcancer graftcancer growthcell cyclecell kineticscell proliferationdna synthesisnuclear medicineradiationradiobiologyratrhabdomyosarcomasarcoma celltheoretical studyAnimalCell DivisionCesium IsotopesDNANeoplasms, ExperimentalRadiation EffectsRatsRats, Inbred StrainsRhabdomyosarcoma
TNO Identifier
227563
Repository link
https://resolver.tno.nl/uuid:3e387017-cc08-4e21-94f5-116e492b7333
ISSN
02775379
Source
European Journal of Cancer and Clinical Oncology, 9(10), pp. 753-756.
Pages
753-756
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