Cell killing effectiveness of an alkylating steroid (Leo 1031): letter

article


Evenaar, A.H.

Wins, E.H.R.

Putten, L.M. van
A steroid with a bis chloro aethylamino phenyl butyric acid group in the side chain was prepared (pregna 1, 4 diene 3, 20 dione, 11β, 17α, 21 trihydroxy, 21 4 p/bis (2 chloro aethyl) amino/phenyl, butyrate (EORTC 1502, NSC 134087)). This report describes the effectiveness of this compound, after subcutaneous injection in mice, on the survival of resting and rapidly proliferating haemopoietic stem cells and of L1210 leukaemia cells, as well as on transplantable osteosarcoma.
Chemicals/CAS: prednimustine, 29069-24-7; Ketosteroids; Nitrogen Mustard Compounds; Pregnadienetriols
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alkylating agentprednimustinesteroid hormonebone marrowbone marrow cellcancer graftcellcell proliferationchemotherapycytolysisdose responsehematopoietic cellleukemia cellleukemia l 1210osteosarcomapharmacologyAnimalCell DivisionInjections, SubcutaneousKetosteroidsLeukemia L1210MiceMice, Inbred StrainsNeoplasms, ExperimentalNitrogen Mustard CompoundsOsteosarcomaPregnadienetriols
TNO Identifier
227551
Repository link
https://resolver.tno.nl/uuid:264306bb-57e9-4583-b7fc-df14111a2083
ISSN
02775379
Source
European Journal of Cancer and Clinical Oncology, 9(10), pp. 773-774.
Pages
773-774
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