Spontaneous lesions in the female WAG/Rij (Wistar) rat
article
An awareness of spontaneous lesions occurring in an experimental animal is essential in evaluating long term experiments in that animal; it is especially crucial in gerontological studies. With this in mind, rats from several strains were set aside specifically to determine incidences of various lesions occurring during aging. The female WAG/Rij (Wistar derived) rat was the first animal to be investigated. The rats were allowed to complete their life span, and 290 female WAG/Rij rats had an average life span of 31 mth. (range 11 to 43). In these animals, a total of 519 tumors was seen histologically, almost 80% of which involved the endocrine glands. The most common tumor, adenoma of the pituitary, was found in 69% of all females. Two unusual tumors were a mesothelioma of the pleura, occurring in a 39 mth old rat and an ameloblastic fibro odontoma in the jaw of a 28 mth old rat. Tumors, and not degenerative or infectious lesions, were the main reason for the rat coming to necropsy.
Topics
adenomaageameloblastomacancer growthcancer incidencediagnosisgeriatricshypophysis tumormesotheliomapleura cancerrattheoretical studyAdenomaAdenoma, ChromophobeAdrenal Gland NeoplasmsAgingAnimalCarcinomaEndocardiumFemaleLiverLongevityMammaeMesotheliomaMyocardiumNeoplasm MetastasisNeoplasmsNeoplasms, Multiple PrimaryPancreasPituitary NeoplasmsPleural NeoplasmsRatsRats, Inbred StrainsRodent DiseasesThyroid Neoplasms
TNO Identifier
227502
ISSN
00221422
Source
Journals of Gerontology, 28(2), pp. 152-159.
Pages
152-159
Files
To receive the publication files, please send an e-mail request to TNO Repository.