In vivo gp39-CD40 interactions occur in the non-follicular compartments of the spleen and are essential for thymus dependent antibody responses and germinal center formation
bookPart
The initiation of thymus-dependent (TD) antibody responses requires class ll-restricted antigen-specific helper T cell cognate interactions with B cells. None of the molecularly cloned cytokines, alone or in combination, can replace the contact-dependent requirement for B cell activation1. The molecule which mediates the contact-dependent signal is a 39 kD membrane protein which is expressed on the surface of activated T-helper (Th) cells2,3. This membrane protein, gp39, was identified as the ligand for the B cell membrane protein CD40. CD40, a mitogenic receptor expressed on all mature B lymphocytes4, is a type I membrane protein and member of the TNF receptor family5. Evidence that CD40 is an important receptor on B cells is derived from studies that anti-CD40 mAb and cofactors such as anti-immunoglobulin (Ig) and cytokines initiate both B cell growth and differentiation6,7. Chemicals/CAS: Antigens, CD; Antigens, CD40; Antigens, Differentiation, B-Lymphocyte; CD40 Ligand, 147205-72-9; Membrane Glycoproteins; Trinitrobenzenes
Topics
cd40 antigenmembrane proteinanimal cellantibody responseantigen bindingb lymphocyteb lymphocyte activationb lymphocyte differentiationcell interactionconference papergerminal centermemory cellmousenonhumanpriority journalprotein protein interactionsignal transductiont lymphocyteAnimalAntibody FormationAntigens, CDAntigens, CD40Antigens, Differentiation, B-LymphocyteB-LymphocytesCD40 LigandImmunologic MemoryLymphocyte ActivationLymphocyte CooperationMembrane GlycoproteinsMiceMice, Inbred BALB CMice, Inbred C57BLMice, Inbred CBASpleenT-Lymphocytes, Helper-InducerTrinitrobenzenes
TNO Identifier
232793
ISBN
978-1-4613-6062-9
Publisher
Springer
Source title
Advances in Experimental Medicine and Biology: in vivo immunology: Regulatory Processes during Lymphopoiesis
and Immunopoiesis
and Immunopoiesis
Editor(s)
Heinen, E.
Defresne, M.P.
Boniver, J.
Geenen, V.
Defresne, M.P.
Boniver, J.
Geenen, V.
Place of publication
Boston, MA
Pages
75-80
Files
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