The influence of the thymus upon the number and class distribution of immunoglobulin containing cells in the bone marrow and other lymphoid organs of the mouse
conference paper
Due to the lack of mature T-cells, congenitally athymic (nude) mice have severely decreased serum IgG and IgA levels, together with normal or enhanced serum IgM levels (1–3). The cells responsible for the synthesis of these immunoglobulins are demonstrable as cytoplasmic immunoglobulin containing cells (C-Ig cells) by means of immunofluorescence (4). C-Ig cell numbers in the spleen are comparable in young and adult nude and heterozygous mice, whereas the age-related increase of the C-Ig cell population in the other lymphoid organs is retarded in nude mice (5). This is especially true for the bone marrow, which contains the majority of all C-Ig cells in thymus-bearing mice at adult age (5–7). In this paper the effect of thymus transplantation was studied upon the number and class distribution of C-Ig cells in spleen, bone marrow, mesenteric lymph node and Peyer’s patches of nude mice. © 1979 Plenum Press
TNO Identifier
355193
Publisher
Plenum Publishing
Source title
Function and structure of the immune system
Editor(s)
Müller-Ruchholtz, W.
Müller-Hermelink, H.K.
Müller-Hermelink, H.K.
Place of publication
S.l.
Pages
133-138
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