The role of T and suppressor cells in MTV directed cellular immunity

article

Creemers, P.

Bentvelzen, P.
The lymphocyte population from mice immunized with mammary tumor virus (MTV) which responds in vitro with blastogenesis in the presence of MTV, proves to consist of T cells. In mice bearing spontaneous MTV induced mammary tumors, this T cell reactivity was very often depressed. The depression was partly due to the presence of suppressor cells which have adherent properties. These suppressor cells appear early during tumor growth and exert their greatest influence when the tumor weighs 0.5-1.5 g. In animals bearing larger tumors less suppressor cells were present and the hyporeactivity in the lymphocyte stimulation test must also be due to other factors.
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virus vaccinecancer growthcellular immunitylymphocyte transformationmousemouse mammary tumor oncovirusoncovirinaesuppressor cellt lymphocytetheoretical studyAnimalImmunity, CellularImmunosuppressionLymphocyte ActivationMammary Tumor Virus, MouseMiceSupport, U.S. Gov't, P.H.S.T-Lymphocytes
TNO Identifier
228159
Repository link
https://resolver.tno.nl/uuid:a2f35109-7f0d-4911-8214-e9630e5492e7
ISSN
02775379
Source
European Journal of Cancer and Clinical Oncology, 13(3), pp. 261-267.
Pages
261-267
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