In vitro effect of thymic epithelial culture supernatant (TES) on T cell markers and functions
conference paper
This chapter discusses the in vitro effect of thymic epithelial culture supernatant (TES) on T cell markers and functions. The hydrocortisone (HC)-resistant pool of mouse thymocytes is derived from some HC-sensitive precursor cells present in the thymic cortex. The chapter presents a study that investigated whether TES could enlarge the HC-resistant thymocyte population. The data presented in the chapter shows that the presence of TES increases the number of HC-resistant thymocytes. Because T cell-proliferative capacity in HC-sensitive thymocytes, and not in the HC-resistant population, could also be enhanced by TES and the HC-resistant cells exhibit similar functional properties as mature T cells, these data might possibly be regarded as reflecting a T cell-maturation process. The increase in intracellular cyclic AMP levels, the induction of HC-resistance, and the reduction in Thy 1-density induced by TES are accompanied by enhancement or induction of various T cell functions. Although thymocytes do not literally belong to the class of postthymic precursors, they can be regarded as post-thymic precursors on an operational basis. Copyright © 1979 ACADEMIC PRESS, INC. Published by Elsevier Inc. All rights reserved.
Topics
TNO Identifier
356207
Publisher
Academic Press
Source title
Cell Biology and Immunology of Leukocyte Function, Proceedings of the Twelfth International Leukocyte Culture Conference, Beer Sheva, 1978
Editor(s)
Quastel, M.R.
Place of publication
New York
Pages
215-219
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