Effectiveness of P-aminobenzyol-O-phenylenediamine (Goe 1734) against mouse, rat, and human tumour cells

article


Lelieveld, P.

Middeldorp, R.J.F.

Putten, L.M. van
The new N-phenylbenzamide derivative Goe 1734 was tested for its antitumour effects against mouse, rat, and human tumours. The preparation showed marginal activity against leukaemia L1210, moderate activity against Lewis lung carcinoma, and high activity against osteosarcoma C22LR and Brown Norway myeloid leukaemia. In the subrenal capsule assay the drug was active against four (cisplatin: 2) of nine human tumours. An in vitro clonogenic assay did not reveal any activity of Goe 1734 when mouse osteosarcoma or human tumour cells were exposed for only 1 h. However, continuous exposure led to 70% or greater inhibition of colony formation at concentrations of 0.1-1 microgram/ml (osteosarcoma) or 0.2-2 micrograms/ml (human tumours).
Chemicals/CAS: dinaline, 58338-59-3; dinaline, 58338-59-3; Phenylenediamines
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dinalinephenylenediamine derivativeanimalarticlecolon tumordrug screeningfemalehumanleukemia L 1210lung tumormouseneoplasmosteosarcomaovary tumorratAnimalColonic NeoplasmsDrug Evaluation, PreclinicalFemaleHumanLeukemia L1210Lung NeoplasmsMiceNeoplasmsOsteosarcomaOvarian NeoplasmsPhenylenediaminesRatsSupport, Non-U.S. Gov'tTumor Stem Cell Assay
TNO Identifier
229850
Repository link
https://resolver.tno.nl/uuid:677bff24-7f8e-4dc8-84f8-0c383913acc1
ISSN
03445704
Source
Cancer Chemotherapy and Pharmacology, 15(1), pp. 88-90.
Pages
88-90
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