Comparison of metastatic disease after local tumour treatment with radiotherapy or surgery in various tumour models
article
Spontaneous metastases in lymph nodes and/or the lung were obtained after tumour cell inoculation of four mouse tumours and one rat tumour into the footpads of syngeneic animals or their F1 hybrids. Following local radiotherapy with doses of 45-80 Gy, significantly more mice died with metastases than following local amputation of the tumour-bearing foot when the 2661 carcinoma was involved. No significant difference was observed after these treatments for the other tumours. The enhancement of metastastic growth after local rad
iotherapy in the 2661 carcinoma seems not to be due to incomplete killing of tumour cells in the foot. The presence of irradiated normal structures and tumour tissue after radiotherapy promoted the outgrowth of 2661 carcinoma cells which were outside the radiation field at the time of treatment. Evidently, even under similar experimental conditions, radiotherapy may enhance the growth of metastases from some tumours and not from others.
iotherapy in the 2661 carcinoma seems not to be due to incomplete killing of tumour cells in the foot. The presence of irradiated normal structures and tumour tissue after radiotherapy promoted the outgrowth of 2661 carcinoma cells which were outside the radiation field at the time of treatment. Evidently, even under similar experimental conditions, radiotherapy may enhance the growth of metastases from some tumours and not from others.
Topics
antineoplastic agentanimal experimentanimal modelbiological modelcancer chemotherapycancer graftcancer radiotherapycancer surgerylung metastasislymph node metastasislymphatic systemmetastasismouseradiotherapyrespiratory systemtherapyAmputationAnimalCell SurvivalComparative StudyDose-Response Relationship, DrugFoot DiseasesHindlimbLung NeoplasmsLymphatic MetastasisMiceMice, Inbred StrainsNeoplasm TransplantationNeoplasms, ExperimentalRadiotherapy DosageRatsRats, Inbred StrainsSupport, U.S. Gov't, P.H.S.
TNO Identifier
229201
ISSN
02775379
Source
European Journal of Cancer and Clinical Oncology, 18(3), pp. 281-289.
Pages
281-289
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