Ftorafur : A self-limiting source of 5-fluorouracil?
article
Studies of the cell killing effectiveness of ftorafur were carried out against 5-fluorouracil (5-FU). It appeared that in divided doses ftorafur is both relatively less toxic in terms of LD50 and bone marrow stem cell killing and less effective against L1210 and a mouse osteosarcoma than 5-FU. Pharmacokinetic analysis revealed that upon repeated administration of 5-FU there is an increase in late drug serum levels and a decreased clearance of 5-FU from the serum. Repeated administration of ftorafur is not associated with significant differences in serum levels of 5-FU or ftorafur. It is concluded that the relatively good tolerance to divided doses of ftorafur in comparison with divided doses of 5-FU may be a consequence of the pharmacokinetic differences.
Chemicals/CAS: fluorouracil, 51-21-8; tegafur, 17902-23-7; Fluorouracil, 51-21-8; Tegafur, 17902-23-7
Chemicals/CAS: fluorouracil, 51-21-8; tegafur, 17902-23-7; Fluorouracil, 51-21-8; Tegafur, 17902-23-7
Topics
TNO Identifier
228731
ISSN
03445704
Source
Cancer Chemotherapy and Pharmacology, 3(1), pp. 61-66.
Pages
61-66
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