Ageing and the thymus-dependent immune system
article
T cell proliferative capacity (induced by mitogens or alloantigens) of spleen and blood lymphocytes from aged rats is decreased due to a decrease in the number of reactive cells. The extent of the decrease was found to be thymus-related. In the thymus, a loss of cells (both relative and absolute) sensitive to the effects of a certain source of thymic factors occurs with advancing age. In young rats, such factors can enhance or induce T cell stimulation in thymocytes which respond only poorly to mitogens and alloantigens without thymic factor treatment.
TNO Identifier
228479
ISSN
03781186
Source
Nederlands Tijdschrift voor Gerontologie, 9(4), pp. 220-224.
Pages
220-224
Files
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