Experimental studies on the combination of radiation and chemotherapy
article
Experimental studies were performed to evaluate the effect of approximately simultaneous application of radiation and a number of widely used cytostatic agents. Effects were tested in five systems: (a) Normal mouse haemopoietic spleen colony forming stem cells; (b) The same cells when induced to proliferate rapidly; (c) L1210 leukemia cells; (d) and (e) Microtumors in the lung, exposed to combined treatment at respectively 24 hr and 96 hr after intravenous inoculation of osteosarcoma cells in mice. Responses to combined treatment were different in the different test systems and so far no agent was identified which showed potentiation in all malignant cell systems tested. The difficulties in evaluating the results of simple tests are discussed.
Chemicals/CAS: bleomycin, 11056-06-7; cytarabine, 147-94-4, 69-74-9; daunorubicin, 12707-28-7, 20830-81-3, 23541-50-6; doxorubicin, 23214-92-8, 25316-40-9; etoposide, 33419-42-0; fluorouracil, 51-21-8; hydroxyurea, 127-07-1; methotrexate, 15475-56-6, 59-05-2, 7413-34-5; semustine, 13909-09-6; vinblastine, 865-21-4; vincristine, 57-22-7; Antineoplastic Agents
Chemicals/CAS: bleomycin, 11056-06-7; cytarabine, 147-94-4, 69-74-9; daunorubicin, 12707-28-7, 20830-81-3, 23541-50-6; doxorubicin, 23214-92-8, 25316-40-9; etoposide, 33419-42-0; fluorouracil, 51-21-8; hydroxyurea, 127-07-1; methotrexate, 15475-56-6, 59-05-2, 7413-34-5; semustine, 13909-09-6; vinblastine, 865-21-4; vincristine, 57-22-7; Antineoplastic Agents
Topics
bleomycincytarabinedaunorubicindoxorubicinetoposidefluorouracilhydroxyureamethotrexatesemustinevinblastinevincristineanimal experimentbonecancer chemotherapyhematopoietic cellintravenous drug administrationleukemia cellleukemia l 1210lung tumormitoposidemouseosteosarcomaradiosensitizationradiotherapytherapyX rayAnimalAntineoplastic AgentsCell SurvivalDose-Response Relationship, DrugLeukemia L1210MiceNeoplasm TransplantationNeoplasms, ExperimentalOsteosarcomaSupport, U.S. Gov't, P.H.S.X-Rays
TNO Identifier
228364
ISSN
03603016
Source
International Journal of Radiation Oncology Biology Physics, 4(1-2), pp. 37-41.
Pages
37-41
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