Respiratory activities of hepatocytes isolated from rats of various ages. A brief note

article


Brouwer, A.

Bezooijen, C.F.A. van

Knook, D.L.
The ratio between the oxygen consumption of isolated hepatocytes in the presence of an inhibitor of oxidative phosphorylation (oligomycin, atractyloside) and in the presence of an uncoupler (dinitrophenol) is used as an estimation of the respiratory control ratio of mitochondria inside the isolated liver parenchymal cell. No significant age-related decline in the functional integrity of the mitochondria could be detected.
Chemicals/CAS: 2,4 dinitrophenol, 25550-58-7, 51-28-5; atractyloside, 17754-44-8; oligomycin, 1404-19-9; Atractyloside, 17754-44-8; Dinitrophenols; Oligomycins
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2,4 dinitrophenolatractylosideoligomycinageagingcell metabolismin vitro studyliver cellmethodologymitochondrionphosphorylationrattheoretical studyAgingAnimalAtractylosideDinitrophenolsFemaleIn VitroLiverMitochondria, LiverOligomycinsOxidative PhosphorylationOxygen ConsumptionRats
TNO Identifier
228279
Repository link
https://resolver.tno.nl/uuid:594583ab-a44b-421e-99a4-17da0c3c7601
ISSN
00476374
Source
Mechanisms of Ageing and Development, 6(4), pp. 265-269.
Pages
265-269
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