The effect of cytostatic hexitol derivatives on haematopoietic stem cells, the L1210 leukaemia and C22LR osteosarcoma
article
In a comparative study the effect of six hexitol derivatives, mannomustine, mitobronitol, dianhydromannitol, mitolactol, dianhydrodulcitol and dimesyldianhydroiditol (DMDAI) on haematopoietic stem cells was studied by the spleen colony technique. All drugs investigated, except DMDAI, have a low ratio of effectiveness on resting compared to rapidly proliferating stem cells. In the L1210 system, the drugs have less effect on the leukemic cells than on the rapidly proliferating haematopoietic stem cells. In the C22LR osteosarcoma solid tumour system, the hexitol derivatives present a moderate or strong antitumour activity. Among the drugs studied, DMDAI deserves special attention, because of its sparing effect on resting haematopoietic stem cells.
Chemicals/CAS: mannomustine, 551-74-6, 576-68-1; mitobronitol, 488-41-5; mitolactol, 10318-26-0; Antineoplastic Agents; Ethers, Cyclic; Galactitol, 608-66-2; Mannitol, 69-65-8; Mesylates; Mitobronitol, 488-41-5; Mitolactol, 10318-26-0; Mustard Compounds; Sugar Alcohols
Chemicals/CAS: mannomustine, 551-74-6, 576-68-1; mitobronitol, 488-41-5; mitolactol, 10318-26-0; Antineoplastic Agents; Ethers, Cyclic; Galactitol, 608-66-2; Mannitol, 69-65-8; Mesylates; Mitobronitol, 488-41-5; Mitolactol, 10318-26-0; Mustard Compounds; Sugar Alcohols
Topics
antineoplastic agentmannomustinemitobronitolmitolactolanhydrogalactitolbacterium clearancebone marrow cellcancercancer graftcell proliferationchemotherapydrug comparisongalactitol derivativehematopoietic cellhexitolhexitol derivativein vitro studyleukemialeukemia cellleukemia l 1210mannitol derivativeosteosarcomatheoretical studyAnimalAntineoplastic AgentsCell SurvivalComparative StudyDose-Response Relationship, DrugEthers, CyclicFemaleGalactitolHematopoietic Stem CellsInjections, IntravenousLethal Dose 50Leukemia L1210MaleMannitolMesylatesMiceMice, Inbred StrainsMitobronitolMitolactolMustard CompoundsOsteosarcomaRadiation ChimeraSugar Alcohols
TNO Identifier
227894
ISSN
02775379
Source
European Journal of Cancer and Clinical Oncology, 11(3), pp. 169-173.
Pages
169-173
Files
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