Lesions characteristics of secondary disease in germfree heterologous radiation chimeras
article
Germfree Swiss mice were given a lethal dose of X radiation and then treated with rat bone-marrow cells. A histologic study of the tissues of these mice at various intervals up to 80 days after irradiation revealed lesions in the lymphatic tissues, the skin, the intestinal tract, and the liver that were characteristic of graft-versus-host disease. In contrast to previous findings in conventional animals, these lesions were not complicated by inflammatory changes.
TNO Identifier
354972
Source
Journal of the National cancer institute, 38, pp. 223-231.
Pages
223-231
Files
To receive the publication files, please send an e-mail request to TNO Repository.