Macrophage migration inhibitory factor (MIF): Mechanisms of action and role in disease

article




Lue, H.

Kleemann, R.

Calandra, T.

Roger, T.

Bernhagen, J.
Macrophage migration inhibitory factor (MIF) is a unique cytokine and critical mediator of host defenses with a role in septic shock and chronic inflammatory and autoimmune diseases. Its mechanism of action is incompletely understood. Here, we attempt to correlate current knowledge on the molecular pathways of MIF activity with its functions in immunity and disease. © 2002 Éditions scientifiques et médicales Elsevier SAS. All rights reserved.
Chemicals/CAS: COPS5 protein, human, EC 3.4.-.-; DNA-Binding Proteins; Intracellular Signaling Peptides and Proteins; macrophage migration inhibitory factor receptor; Macrophage Migration-Inhibitory Factors; Peptide Hydrolases, EC 3.4.-; Receptors, Immunologic; Transcription Factors
Topics














AnimalsArteriosclerosisArthritis, RheumatoidDNA-Binding ProteinsGlomerulonephritisHumansIntracellular Signaling Peptides and ProteinsLung DiseasesMacrophage Migration-Inhibitory FactorsNeoplasmsPeptide HydrolasesReceptors, ImmunologicShock, SepticSignal TransductionTranscription Factors
TNO Identifier
236517
Repository link
https://resolver.tno.nl/uuid:89ab7476-d7bd-43c9-a40f-eb7498ceaccb
ISSN
12864579
Source
Microbes and Infection, 4(4), pp. 449-460.
Pages
449-460
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