Brief Communication: High incidence of spontaneous urinary bladder and ureter tumors in the brown Norway rat
article
The incidence of spontaneous urinary bladder and ureter tumors was unusually high in the Brown Norway rat. Tumors of the bladder epithelium were found in 28% of the males and 2% of the females; 20% of the females and 6% of the males had ureter tumors. Most bladder neoplasms were papillary tumors covered by a thickened and moderately pleomorphic transitional epithelium. Many of the ureter tumors were squamous cell carcinomas with marked keratinization. Metastasis occurred in 4 rats with ureter tumors and 1 rat with bladder tumor. Another rat strain kept at our institute at the same time under identical conditions did not develop these tumors. Preliminary data suggest a correlation between the occurrence of tumors and the urinary calculi frequently found in this strain. The Brown Norway rat may thus be a useful animal model for the study of urinary bladder tumors.
Topics
TNO Identifier
227790
ISSN
00278874
Source
Journal of the National Cancer Institute, 52(3), pp. 1005-1006.
Pages
1005-1006
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