Transplantable calcitonin secreting medullary carcinomas of the thyroid in the WAG/Rij rat
article
Bioassay of medullary thyroid carcinomas occurring spontaneously in older WAG/Rij rats revealed high levels of calcitonin activity in the tumor tissue. Of 10 such spontaneous carcinomas transplanted to young WAG/Rij recipients, 7 grew. Several transplantation lines are being maintained. The tumors usually grew slowly and progressively. The hosts died 7-11 mth after receiving the transplant, often from an adenoma of the pituitary. Calcitonin activity was demonstrated both in the tumor transplant and in the serum of the tumor bearing rats. In a preliminary experiment, calcitonin secretion by tumor tissue in vitro was stimulated by addition of pentagastrin.
Chemicals/CAS: calcitonin, 12321-44-7, 21215-62-3, 9007-12-9; pentagastrin, 5534-95-2; Calcitonin, 9007-12-9; Pentagastrin, 5534-95-2
Chemicals/CAS: calcitonin, 12321-44-7, 21215-62-3, 9007-12-9; pentagastrin, 5534-95-2; Calcitonin, 9007-12-9; Pentagastrin, 5534-95-2
Topics
calcitoninpentagastrincancer grafthypophysis adenomamedullary carcinomamethodologyrattheoretical studythyroid carcinomathyroid medullary carcinomaAnimalBiological AssayCalcitoninCarcinomaFemaleMaleNeoplasm TransplantationNeoplasms, ExperimentalPentagastrinRatsThyroid NeoplasmsTransplantation, Homologous
TNO Identifier
227708
ISSN
00278874
Source
Journal of the National Cancer Institute, 53(4), pp. 1011-1015.
Pages
1011-1015
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