Clearance of antibiotics from the intestines after termination of antibiotic decontamination
article
The clearance of neomycin and kanamycin from the intestines after stopping oral supply has been determined in mice. Both antibiotics, although given in different doses, were excreted in essentially the same way; the clearance being a little faster than logarithmically in both cases. The importance of this observation with regard to isolation and the moment of reconventionalization is discussed.
Chemicals/CAS: bacitracin, 1405-87-4; kanamycin, 11025-66-4, 61230-38-4, 8063-07-8; natamycin, 52882-37-8, 7681-93-8; neomycin, 11004-65-2, 1404-04-2, 1405-10-3, 8026-22-0; Bacitracin, 1405-87-4; Dyes; Kanamycin, 59-01-8; Neomycin, 1404-04-2
Chemicals/CAS: bacitracin, 1405-87-4; kanamycin, 11025-66-4, 61230-38-4, 8063-07-8; natamycin, 52882-37-8, 7681-93-8; neomycin, 11004-65-2, 1404-04-2, 1405-10-3, 8026-22-0; Bacitracin, 1405-87-4; Dyes; Kanamycin, 59-01-8; Neomycin, 1404-04-2
Topics
bacitracinkanamycinnatamycinneomycindiagnostic agentdyedrug clearancedrug excretionintestineintestine floramouseoral drug administrationtheoretical studyanimalfecesfemalegermfree animalintestine absorptionmetabolismmicrobiologyperistalsissmall intestinetimeAnimalBacitracinDyesFecesFemaleGerm-Free LifeIntestinal AbsorptionIntestine, SmallIntestinesKanamycinMiceNeomycinPeristalsisTime Factors
TNO Identifier
227666
ISSN
00221724
Source
Journal of Hygiene, 73(3), pp. 409-414.
Pages
409-414
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