Effect of hyperthermia on the radiation response of two mammalian cell lines
article
The interaction of 43°C hyperthermia and X-irradiation was compared in vitro in two cell lines: Chinese hamster ovary (HA-1) and mouse mammary sarcoma (EMT-6). In HA-1 cells the sequence of heating followed by X-irradiation resulted in appreciably more sensitization than the opposite sequence; in EMT-6 cells the opposite occurred. When time at 37°C was introduced between the two treatments, the degree of interaction was reduced, depending upon sequence and the duration of the 37°C time interval. In both cell lines, maximum toxicity was seen if the two treatments followed each other immediately.
Topics
TNO Identifier
354022
Source
European Journal of Cancer, 13, pp. 65-69.
Pages
65-69
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