Reoxygenation between radiotherapy fractions in an experimental osteosarcoma

article


Putten, L.M. van

Ruiter, J. de

Vecht, B. van der
The hitherto poorly reoxygenating osteosarcoma C22LR was studied by determining the fraction of hypoxic cells in the tumour before irradiation and at 24 and 48 hr after exposure of the tumour to a dose of 10 Gy of X-rays. The comparison of the hypoxic cell fractions as determined at different time points in the history of the osteosarcoma since 1957 suggests that a real change has occurred in the tumour properties. It appears unlikely that the minor changes in cellular sensitivity to a radiation dose of 10 Gy could be the complete explanation of the apparent good reoxygenation of the tumour. (U.K.). Chemicals/CAS: oxygen, 7782-44-7; Oxygen, 7782-44-7
Topics














oxygenanimalcell survivalmetabolismmousemouse strainosteosarcomaradiation exposureAnimalCell SurvivalMiceMice, Inbred StrainsOsteosarcomaOxygenSupport, Non-U.S. Gov't
TNO Identifier
229963
Repository link
https://resolver.tno.nl/uuid:6354b246-dc38-415f-bb3f-6110a966ac8a
ISSN
02775379
Source
European Journal of Cancer and Clinical Oncology, 21(12), pp. 1561-1562.
Pages
1561-1562
Files
To receive the publication files, please send an e-mail request to TNO Repository.