Short term extreme increases in plasminogen activator inhibitor 1 (PAI-1) in plasma of polytrauma patients
article
In 20 polytrauma patients, variations in plasma capacity to inhibit tissue-type plasminogen activator (t-PA) was followed for 48 h with frequent blood sampling, 6 hourly. Extreme increases in PAI activity (at the average 18-fold) were observed 6-12 h after trauma. The increase was due to plasminogen activator inhibitor 1 (PAI-1) as identified by neutralisation of inhibition with a specific monoclonal antibody. The increased PAI-1 activity rapidly reverted to normal, with a half-life of effect in 5 out of 20 patients below 2 h. On average only about 1/10 of the increase is left at t = 24 h. It is concluded that extreme increases in PAI-1 activity can occur at short time intervals after trauma, putting PAI-1 among major acute phase reactants. Frequent blood sampling is required to properly assess the fluctuations.
Chemicals/CAS: plasminogen activator inhibitor 1, 140208-23-7; tissue plasminogen activator, 105913-11-9
Chemicals/CAS: plasminogen activator inhibitor 1, 140208-23-7; tissue plasminogen activator, 105913-11-9
Topics
TNO Identifier
230605
ISSN
02689499
Source
Fibrinolysis, 2(4), pp. 223-226.
Pages
223-226
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