The influence of fibrin(ogen) fragments on the kinetic parameters of the tissue-type plasminogen-activator-mediated activation of different forms of plasminogen

article




Nieuwenhuizen, W.

Voskuilen, M.

Vermond, A.

Hoegee-de Nobel, B.

Traas, D.W.
CNBr fragment 2, Aα 148-207 and to some extent D-EGTA mimic the accelerating effect of fibrin. The first two of these fragments did not accelerate activation of mini-plasminogen, lacking the kringle structures I-IV. This suggests that the stimulating effects of these two fragments were dependent on the presence of kringles I-IV of the plasminogen molecule.
Chemicals/CAS: fibrin, 9001-31-4; fibrinogen, 9001-32-5; plasmin, 9001-90-5, 9004-09-5; plasminogen, 9001-91-6; Cyanogen Bromide, 506-68-3; Fibrin Fibrinogen Degradation Products; Fibrinogen, 9001-32-5; Plasminogen, 9001-91-6; Tissue Plasminogen Activator, EC 3.4.21.68
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fibrinfibrinogenplasminplasminogenfemalehuman cellmalenormal humanplasmapriority journalCatalysisCyanogen BromideEnzyme ActivationFibrin Fibrinogen Degradation ProductsFibrinogenHumanHydrolysisKineticsPlasminogenTissue Plasminogen Activator
TNO Identifier
230512
Repository link
https://resolver.tno.nl/uuid:3ed83deb-9119-4b2b-8b02-cff8a848ea9b
ISSN
00142956
Source
European Journal of Biochemistry, 174(1), pp. 163-169.
Pages
163-169
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