Blood transfusions induce prolonged kidney allograft survival in rhesus monkeys

article




Es, A.A. van

Marquet, R.L.

Rood, J.J. van

Kalff, M.W.

Balner, H.
A prospective study was carried out in rhesus monkeys to investigate the influence of blood-transfusions on kidney allograft survival. Unrelated animals matched for 2 or 3 antigens of the A and B locus of the major histocompatibility complex were given 5 consecutive blood-transfusions before transplantation and received conventional immunosuppressive treatment. Transfused recipients showed a four-fold increase in mean survival time compared with the non-transfused controls. These results may contribute to a change of policy regarding blood-transfusions in transplant patients.
Chemicals/CAS: Azathioprine, 446-86-6; Histocompatibility Antigens; Prednisolone, 50-24-8
Topics


























blood transfusiongraft survivalimmunological tolerancekidney transplantationmajor histocompatibility complexmonkeytheoretical studyAnimalAntibody FormationAzathioprineBlood TransfusionFemaleGraft SurvivalHaplorhiniHistocompatibility AntigensHistocompatibility TestingKidneyKidney TransplantationMacacaMacaca mulattaMalePostoperative CarePrednisolonePreoperative CareProspective StudiesTime FactorsTransplantation, Homologous
TNO Identifier
228303
Repository link
https://resolver.tno.nl/uuid:1a237d77-fdeb-4dd4-bf6c-c91241f6c6e1
ISSN
01406736
Source
Lancet, 1(8010), pp. 506-509.
Pages
506-509
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