Serial transfer of isologous and homologous hematopoietic cells in irradiated hosts
conference paper
Isologous bone marrow and spleen cells have been serially transplanted into irradiated mice using various intervals and cell numbers. In order to maintain the transfer line large numbers of cells and intervals of at least a month are required. The failure to maintain transfer lines on a schedule of intervals of 14 days or less is attributed to the increasing proportion of immature cells in the hematopoietic tissues. C57BL cells have been transferred through 4 passages of F_1 (CBA x C57BL) hybrid mice. The results obtained with a variety of experimental techniques, are suggestive of the development of a specific tolerance of the transferred cells toward the CBA tissue antigen. Alternative explanations for the observed phenomena have been discussed.
TNO Identifier
357049
Source title
Pathologie and Biologie
Pages
888-893
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