The effect of anaesthesia on the radiosensitivity of rat intestine, foot skin and R-1 tumours
article
A comparison has been made of the effects of Nembutal (sodium pentobarbital) and Ethrane (2-chloro-1,1,2-trifluoroethyldifluoromethyl ether) anaesthesia on the radiation responses of rat intestine, foot skin and R-1 rhabdomyosarcoma. Single-dose experiments under Nembutal or short-lasting Ethrane anaesthesia resulted in equivalent radiosensitivities for the R-1 sarcoma and foot skin, whereas Ethrane induced radiosensitization in the intestine. In the Ethrane anaesthesia lasting 3 hours, and in the split-dose experiments, Ethrane inhibited repair of radiation-induced damage in the R-1 sarcoma and in the foot skin. It is therefore recommended that the use of Ethrane as an anaesthetic should be avoided in experiments designed to investigate repair of damage in fractionated studies or during protracted irradiation treatments.
Chemicals/CAS: enflurane, 13838-16-9; pentobarbital, 57-33-0, 76-74-4; Enflurane, 13838-16-9; Pentobarbital, 76-74-4; Radiation-Sensitizing Agents
Chemicals/CAS: enflurane, 13838-16-9; pentobarbital, 57-33-0, 76-74-4; Enflurane, 13838-16-9; Pentobarbital, 76-74-4; Radiation-Sensitizing Agents
Topics
enfluranepentobarbitalRadiation Sensitizing Agentsradiosensitizing agentanesthesiaanimal experimentcentral nervous systemdigestive systemintestinelarge intestinepreliminary communicationradiation injuryratsarcomaskinsmall intestineanimalcomparative studyDNA repairdrug effectgeneral anesthesiaLD 50metabolismradiation doseradiation exposurerhabdomyosarcomatimeAnesthesia, GeneralAnimalComparative StudyDNA RepairEnfluraneIntestinesLethal Dose 50PentobarbitalRadiation DosageRadiation ToleranceRadiation-Sensitizing AgentsRatsRhabdomyosarcomaSarcoma, ExperimentalSkinTime Factors
TNO Identifier
228831
ISSN
09553002
Source
International Journal of Radiation Biology, 37(4), pp. 447-450.
Pages
447-450
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